Lamotrigine is BCS class II drug; hence dissolution is rate-limiting step in its absorption. Oral bioavailability of lamotrigine was improved using inclusion complex formation technique. LMG and HP-β-CD (1:3) was selected as optimized ratio for formation of complex. This complex was formulated into fast dissolving tablet. For preparation of fast dissolving tablet nine formulas were designed using 3² factorial design in which soya polysaccharide and indion 414 were used as superdisintegrants in varying concentration. The effect of types and concentrations of superdisintegrant on the disintegration time and dissolution profile of lamotrigine fast dissolving tablets were studied. The % drug release of fast dissolving tablet prepared using F7 has shown 99.33 % drug release after 6 minutes which was comparable with marketed formulation.
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